学术探索
学术期刊
新闻热点
数据分析
智能评审

PERSISTENT EFFECT OF TGF-BETA-1 ON EXTRACELLULAR-MATRIX GENE-EXPRESSION IN HUMAN DERMAL FIBROBLASTS

被引：41
作者：
ISHIKAWA, O
YAMAKAGE, A
LEROY, EC
TROJANOWSKA, M
机构：
[1] Division of Rheumatology and Immunology, Department of Medicine Medical University of South Carolina, Charleston, SC
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91458-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-β, a potent inducer of the extracellular matrix, is also known to stimulate its own synthesis. In this report we have analyzed long term effects of TGF-β1 on its own expression and on the expression of extracellular matrix genes. We demonstrated that 24 hours of incubation of human dermal fibroblasts with TGF-β1 (1 ng/ml) under serum free conditions resulted in an elevated expression of TGF-β1, collagen α2(I) and fibronectin mRNAs that persisted at least 96 hours after removal of TGF-β1. These data suggest the possibility of persistent in vivo activation of target cells following exposure to TGF-β1. © 1990.
引用
收藏
页码：232 / 238
页数：7
相关论文
共 24 条
123