HOMOCYSTEATE, AN EXCITATORY TRANSMITTER CANDIDATE LOCALIZED IN GLIA

被引：42

作者：

GRANDES, P

DO, KQ

MORINO, P

CUENOD, M

STREIT, P

机构：

[1] UNIV ZURICH, INST BRAIN RES, AUGUST FOREL STR 1, CH-8029 ZURICH, SWITZERLAND

[2] UNIV BASQUE COUNTRY, FAC MED, DEPT NEUROSCI, ANAT SECT, E-48080 BILBAO, SPAIN

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1991年 / 3卷 / 12期

关键词：

EXCITATORY AMINO ACIDS; CEREBELLUM; BERGMANN FIBER; ASTROCYTES; RAT;

D O I：

10.1111/j.1460-9568.1991.tb00070.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

L-Homocysteate, a sulphur-containing L-glutamate analogue has recently been proposed as a neurotransmitter candidate. However, the cellular localization of this excitatory amino acid remained to be determined. By means of immunocytochemistry, the localization of homocysteate was accomplished in the cerebellar cortex of rats. Cerebellar glia could be defined as the major store of this compound. Homocysteate, thus, may not be a classical neurotransmitter but rather a member of another class of intercellular messengers that might be termed 'gliotransmitters'.

引用

页码：1370 / 1373

页数：4

共 27 条

[11]

JONES HE, 1989, J PHYSIOL-LONDON, V417, pP97

[12] L-HOMOCYSTEIC ACID BUT NOT L-GLUTAMATE IS AN ENDOGENOUS N-METHYL-D-ASPARTIC ACID RECEPTOR PREFERRING AGONIST IN RAT NEOCORTICAL NEURONS INVITRO [J].