MECHANISM OF SLOWING OF MUCOCILIARY TRANSPORT INDUCED BY SO2 EXPOSURE

被引:5
作者
MAJIMA, Y
SWIFT, DL
BANG, BG
BANG, FB
机构
[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,BALTIMORE,MD 21218
[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT PATHOBIOL,BALTIMORE,MD 21218
关键词
SULFUR DIOXIDE;
D O I
10.1007/BF02584255
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Responses of nasal mucociliary transport mechanisms to exposure to 6 ppm SO//2 were studied in chickens in vivo. This model takes advantage of the natural cleft palate which exposes the mucociliated base of the nasal septum. Exposure to 6 ppm SO//2 decreased the mucociliary transport rate along the base of the nasal septum. The minimum force required to move an iron particle along this area of mucous membrane by use of a magnetic field in vivo increased significantly after SO//2 exposure, while the minimum force required to move an iron particle on a pool of mucus collected from the same chicken and tested in vitro showed no change after SO//2 exposure. The elastic recoil distance of mucus was measured both in vivo and in vitro. The in vivo recoil distance decreased significantly after SO//2 exposure, while SO//2 exposure did not change recoil distance in vitro.
引用
收藏
页码:515 / 530
页数:16
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