INFLUENCE OF AGING ON THE CONTRACTILE RESPONSE TO ENDOTHELIN OF RAT THORACIC AORTA

被引：29

作者：

ISHIHATA, A ^{[1
]}

KATANO, Y ^{[1
]}

MORINOBU, S ^{[1
]}

ENDOH, M ^{[1
]}

机构：

[1] YAMAGATA UNIV,SCH MED,DEPT PHARMACOL,YAMAGATA 99023,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 200卷 / 01期

关键词：

AGING; ENDOTHELIN-1; ACETYLCHOLINE; AORTA (RAT);

D O I：

10.1016/0014-2999(91)90689-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Age-related changes in the contractile response to endothelin-1 and ACh were assessed in thoracic aortas isolated from 2-, 6- and 24-month-old male Fischer 344 rats. In aortic strips with an intact endothelium, the maximal contractile response to endothelin-1 decreased with development to maturity. Removal of the endothelium did not affect the contractile response to endothelin-1. Endothelin-1 did not elicit a relaxant response in phenylephrine-precontracted strips. The ACh-induced relaxation decreased in senescent rats. These results indicate that the contractile response of aortic smooth muscle to endothelin-1 decreases with age, and that the endothelial vasorelaxant factors do not contribute to this age-induced modulation.

引用

页码：199 / 201

页数：3

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