CD4-TARGETED IMMUNE INTERVENTION - A STRATEGY FOR THE THERAPY OF AIDS AND AUTOIMMUNE-DISEASE

被引：8

作者：

AUFFRAY, C

PIATIERTONNEAU, D

KROEMER, G

机构：

[1] COLL FRANCE, 49BIS AVE BELLE GABRIELLE, F-94736 NOGENT SUR MARNE, FRANCE

[2] CSIC, CTR BIOL MOLEC, MADRID, SPAIN

[3] UNIV AUTONOMA MADRID, MADRID 34, SPAIN

来源：

TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0167-7799(91)90043-H

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.

引用

收藏

页码：124 / 131

页数：8

相关论文

共 32 条

[1] ENHANCEMENT OF SIV INFECTION WITH SOLUBLE RECEPTOR MOLECULES [J].

ALLAN, JS ;

STRAUSS, J ;

BUCK, DW .

SCIENCE, 1990, 247 (4946) :1084-1088

[2] THE BIOLOGIC ROLES OF CD2, CD4, AND CD8 IN T-CELL ACTIVATION [J].

BIERER, BE ;

SLECKMAN, BP ;

RATNOFSKY, SE ;

BURAKOFF, SJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :579-599

[3] THE ROLE OF THE T-CELL RECEPTOR IN POSITIVE AND NEGATIVE SELECTION OF DEVELOPING T-CELLS [J].

BLACKMAN, M ;

KAPPLER, J ;

MARRACK, P .

SCIENCE, 1990, 248 (4961) :1335-1341

[4] PREVENTION OF HIV-1 GLYCOPROTEIN TRANSPORT BY SOLUBLE CD4 RETAINED IN THE ENDOPLASMIC-RETICULUM [J].

BUONOCORE, L ;

ROSE, JK .

NATURE, 1990, 345 (6276) :625-628

[5] BIOLOGICAL PROPERTIES OF A CD4 IMMUNOADHESIN [J].

BYRN, RA ;

MORDENTI, J ;

LUCAS, C ;

SMITH, D ;

MARSTERS, SA ;

JOHNSON, JS ;

COSSUM, P ;

CHAMOW, SM ;

WURM, FM ;

GREGORY, T ;

GROOPMAN, JE ;

CAPON, DJ .

NATURE, 1990, 344 (6267) :667-670

[6] A CD4 DOMAIN IMPORTANT FOR HIV-MEDIATED SYNCYTIUM FORMATION LIES OUTSIDE THE VIRUS BINDING-SITE [J].

CAMERINI, D ;

SEED, B .

CELL, 1990, 60 (05) :747-754

[7] CD4-INDEPENDENT, PRODUCTIVE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF HEPATOMA-CELL LINES INVITRO [J].

CAO, YZ ;

FRIEDMANKIEN, AE ;

HUANG, YX ;

LI, XL ;

MIRABILE, M ;

MOUDGIL, T ;

ZUCKERFRANKLIN, D ;

HO, DD .

JOURNAL OF VIROLOGY, 1990, 64 (06) :2553-2559

[8] DESIGNING CD4 IMMUNOADHESINS FOR AIDS THERAPY [J].

CAPON, DJ ;

CHAMOW, SM ;

MORDENTI, J ;

MARSTERS, SA ;

GREGORY, T ;

MITSUYA, H ;

BYRN, RA ;

LUCAS, C ;

WURM, FM ;

GROOPMAN, JE ;

BRODER, S ;

SMITH, DH .

NATURE, 1989, 337 (6207) :525-531

[9] SELECTIVE KILLING OF HIV-INFECTED CELLS BY RECOMBINANT HUMAN CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN [J].

CHAUDHARY, VK ;

MIZUKAMI, T ;

FUERST, TR ;

FITZGERALD, DJ ;

MOSS, B ;

PASTAN, I ;

BERGER, EA .

NATURE, 1988, 335 (6188) :369-372

[10] SOLUBLE CD4 BLOCKS THE INFECTIVITY OF DIVERSE STRAINS OF HIV AND SIV FOR T-CELLS AND MONOCYTES BUT NOT FOR BRAIN AND MUSCLE-CELLS [J].

CLAPHAM, PR ;

WEBER, JN ;

WHITBY, D ;

MCINTOSH, K ;

DALGLEISH, AG ;

MADDON, PJ ;

DEEN, KC ;

SWEET, RW ;

WEISS, RA .

NATURE, 1989, 337 (6205) :368-370

← 1 2 3 4 →