CD4-TARGETED IMMUNE INTERVENTION - A STRATEGY FOR THE THERAPY OF AIDS AND AUTOIMMUNE-DISEASE

被引：8

作者：

AUFFRAY, C

PIATIERTONNEAU, D

KROEMER, G

机构：

[1] COLL FRANCE, 49BIS AVE BELLE GABRIELLE, F-94736 NOGENT SUR MARNE, FRANCE

[2] CSIC, CTR BIOL MOLEC, MADRID, SPAIN

[3] UNIV AUTONOMA MADRID, MADRID 34, SPAIN

来源：

TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0167-7799(91)90043-H

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.

引用

页码：124 / 131

页数：8

共 32 条

[11] HIGH-CONCENTRATIONS OF RECOMBINANT SOLUBLE CD4 ARE REQUIRED TO NEUTRALIZE PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES [J].