NUMEROUS TRANSITIONS IN HUMAN PARAINFLUENZA VIRUS-3 RNA RECOVERED FROM PERSISTENTLY INFECTED-CELLS

被引：56

作者：

MURPHY, DG ^{[1
]}

DIMOCK, K ^{[1
]}

KANG, CY ^{[1
]}

机构：

[1] UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL,OTTAWA K1H 8M5,ONTARIO,CANADA

来源：

VIROLOGY | 1991年 / 181卷 / 02期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0042-6822(91)90913-V

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequences at the 3'-termini of human parainfluenza virus 3 (HPIV3) genomic RNAs recovered from two lines of persistently infected LLC-MK2 cells were determined following PCR amplification. After 29 months of persistence the 3′-end of the HPIV3 genome was found to be highly mutated. Interestingly, the only types of nucleotide changes observed were U to C and A to G transitions. Both U to C and A to G transitions were present on individual RNA molecules. The data indicate that biased hypermutational activity leading to U To C and A to G mutations operates in cultured cells during persistent HPIV3 infections. © 1991.

引用

页码：760 / 763

页数：4

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