CYTOKINE COMBINATIONS INCREASE P75 TUMOR-NECROSIS-FACTOR RECEPTOR-BINDING AND STIMULATE RECEPTOR SHEDDING IN RHEUMATOID SYNOVIAL FIBROBLASTS

被引：20

作者：

TAYLOR, DJ

机构：

[1] University Department of Medicine, University Hospital of South Manchester, Manchester, West Didsbury

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 02期

关键词：

D O I：

10.1002/art.1780370212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To identify cytokines responsible for the increased levels of tumor necrosis factor receptor (TNFR) in the joints of patients with rheumatoid arthritis. Methods. Antibodies to TNFR types were used both to inhibit ligand cell binding and to quantify released receptors in rheumatoid synovial fibroblasts. Results. Binding by and shedding of the p75 TNFR was affected by interleukin-1 (IL-1), IL-4, and interferon-gamma. Conclusion. IL-1 could cause increased TNF alpha binding and TNFR shedding in inflamed joints.

引用

页码：232 / 235

页数：4

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