KI-1 POSITIVE LARGE CELL ANAPLASTIC LYMPHOMA - MULTIPLE BONE LYTIC LESIONS AND INTERLEUKIN-6

被引：8

作者：

AGEMATSU, K

KOMIYAMA, A

机构：

[1] Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 04期

关键词：

KI-1 LARGE CELL LYMPHOMA; INTERLEUKIN-6; MULTIPLE BONE DESTRUCTION;

D O I：

10.3109/10428199209049783

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ki-1-positive large cell anaplastic lymphoma (Ki-1 LCAL) is recognized as a clinicopathologic syndrome with fever, peripheral lymphadenopathy and cutaneous nodules, the neoplastic cells express Hodgkin's disease-associated antigen, Ki-1 (CD30). We review here a recent case of Ki-1 LCAL with multiple bone lesions with destruction and present additional information. Although bone absorption is reported in some cases of Ki-1 LCAL, the genesis of bone absorption is unclear. Interleukin-6 (IL-6) is an important regulator of osteoclast formation and activation and can induce bone absorption. In our case, the surgically removed tumor tissue was studied for IL-6 mRNA expression and IL-6 secretion without any stimulation. Northern blot analysis showed strong IL-6 mRNA expression in the tumor tissue and ELISA assay showed a large amount of IL-6 in culture supernatants of the tumor tissue. Based on these results, coupled with the reported evidence, we discuss the close relationship between the presence of osteolytic lesions and IL-6 production in Ki-1 LCAL.

引用

页码：309 / 315

页数：7

共 55 条

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