KI-1 POSITIVE LARGE CELL ANAPLASTIC LYMPHOMA - MULTIPLE BONE LYTIC LESIONS AND INTERLEUKIN-6

被引：8

作者：

AGEMATSU, K

KOMIYAMA, A

机构：

[1] Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 04期

关键词：

KI-1 LARGE CELL LYMPHOMA; INTERLEUKIN-6; MULTIPLE BONE DESTRUCTION;

D O I：

10.3109/10428199209049783

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ki-1-positive large cell anaplastic lymphoma (Ki-1 LCAL) is recognized as a clinicopathologic syndrome with fever, peripheral lymphadenopathy and cutaneous nodules, the neoplastic cells express Hodgkin's disease-associated antigen, Ki-1 (CD30). We review here a recent case of Ki-1 LCAL with multiple bone lesions with destruction and present additional information. Although bone absorption is reported in some cases of Ki-1 LCAL, the genesis of bone absorption is unclear. Interleukin-6 (IL-6) is an important regulator of osteoclast formation and activation and can induce bone absorption. In our case, the surgically removed tumor tissue was studied for IL-6 mRNA expression and IL-6 secretion without any stimulation. Northern blot analysis showed strong IL-6 mRNA expression in the tumor tissue and ELISA assay showed a large amount of IL-6 in culture supernatants of the tumor tissue. Based on these results, coupled with the reported evidence, we discuss the close relationship between the presence of osteolytic lesions and IL-6 production in Ki-1 LCAL.

引用

页码：309 / 315

页数：7

共 55 条

[41]

Macdonald B.R., Takahashi N., McManus L.M., Holahan J., Mundy G.R., Roodman G.D., Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures, Endocrinology, 120, pp. 2326-2333, (1987)

[42]

Takahashi N., Yamada H., Yoshiki S., Roodman G.D., Mundy G.R., Jones S.J., Boyde A., Suda T., Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures, Endorcrinologv, 122, pp. 1373-1382

[43]

Kodama H., Ysmasaki A., Nose M., Niida S., Ohgame Y., Abe M., Kunegawa M., Suda T., Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor, J. Exp. Med, 173, pp. 269-272, (1991)

[44]

Thomson B.M., Saklatvala J., Chambers T.J., Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts, J. Exp. Med., 164, pp. 104-112, (1986)

[45]

Thomson B.M., Mundy G.R., Chambers T.J., Tumor necrosis factors a and β induce osteoblastic cells to stimulate osteoclastic bone resorption, J. Immunol, 138, pp. 775-779, (1987)

[46]

Feyen J.H.M., Elford P., DiPadova F.E., Trechsel U., Interleukin-6 is produced by bone and modulated by parathyroid hormone, J. Bone Miner. Res., 4, pp. 633-639, (1989)

[47]

Lowik C., Van der Pluijm G., Hockman K., Aarden J., Bijvoet O., Papapoulos S., IL-6 produced by PTH-stimulated osteogenic cells can be a mediator in osteoclast recruitment, J. Bone Miner. Res., 4, (1989)

[48]

Ouchi Y., Okamoto Y., Masuyama A., Kaneki M., Futami A., Hosoi T., Nakamura T., Orimo H., Effect of parathyroid hormone on release of interleukin-1 and interleukin-6 from cultured mouse osteoblastic cells, Biochem. Biophys. Res. Commun., 179, pp. 236-242, (1991)

[49]

Ishikawa H., Tanaka H., Iwato K., Tanabe O., Asaoku H., Nobuyoshi M., Yamamoto I., Kawano M., Kuramoto A., Effect of glucocorticoids on the biologic activity of myeloma cells: Inhibition of interleukin-1β osteoclast activity factor-induced bone resorption, Blood, 75, pp. 715-720, (1990)

[50]

Bitter M.A., Komaiko W., Franklin W.A., Giant lymph node hyperplasia with osteoblastic bone lesions and the POEMS (Takatsuki's) syndrome, Cancer, 56, pp. 188-194, (1985)

← 1 2 3 4 5 6 →