AN EFFICIENT AND STEREOSELECTIVE SYNTHESIS OF 2',5'-OLIGO-(SP)-THIOADENYLATES

被引：17

作者：

BATTISTINI, C

BRASCA, MG

FUSTINONI, S

LAZZARI, E

机构：

[1] Farmitalia Carlo Erba (Erbamont Group)- Research and Development, 20146 Milano

来源：

TETRAHEDRON | 1992年 / 48卷 / 15期

关键词：

D O I：

10.1016/S0040-4020(01)92259-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2',5'-Phosphorothioato-oligoadenylates have been synthesized with S(P)-stereoselectivity by using hydrogenphosphonate methodology followed by oxidative sulphurization.

引用

页码：3209 / 3226

页数：18

共 37 条

[1]

BARTLETT PA, 1982, J BIOL CHEM, V257, P8879

[2] HIGH STEREOSELECTIVITY IN THE FORMATION OF THE INTER-RIBONUCLEOTIDIC PHOSPHOROTHIOATE BOND [J].

BATTISTINI, C ;

BRASCA, MG ;

FUSTINONI, S .

NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3) :723-725

[3] SYNTHESIS OF P-THIOADENYLYL (2'-5') ADENOSINE AND P-THIOADENYLYL (2'-5')-P-THIOADENYLYL-(2'-5')-ADENOSINE [J].

CHARUBALA, R ;

PFLEIDERER, W .

NUCLEOSIDES & NUCLEOTIDES, 1987, 6 (1-2) :513-516

[4] SYNTHESIS AND PROPERTIES OF 3'-DEOXYADENYLATE TRIMER DA2'P5'A2'P5'A [J].

CHARUBALA, R ;

PFLEIDERER, W .

TETRAHEDRON LETTERS, 1980, 21 (42) :4077-4080

[5] SYNTHESIS OF INOSINATE TRIMER I2'P5'I2'P5'I AND TETRAMER I2'P5'I2'P5'I2'P5'I [J].

CHARUBALA, R ;

PFLEIDERER, W .

TETRAHEDRON LETTERS, 1982, 23 (46) :4789-4792

[6] AN APPROACH TO THE STEREOSELECTIVE SYNTHESIS OF SP-DINUCLEOSIDE PHOSPHOROTHIOATES USING PHOSPHOTRIESTER CHEMISTRY [J].

COSSTICK, R ;

WILLIAMS, DM .

NUCLEIC ACIDS RESEARCH, 1987, 15 (23) :9921-9932

[7] SYNTHESIS OF D(GC) AND D(CG) OCTAMERS CONTAINING ALTERNATING PHOSPHOROTHIOATE LINKAGES - EFFECT OF THE PHOSPHOROTHIOATE GROUP ON THE B-Z TRANSITION [J].

COSSTICK, R ;

ECKSTEIN, F .

BIOCHEMISTRY, 1985, 24 (14) :3630-3638

[8]

CREA R, 1981, J ORG CHEM, V46, P2242

[9] PREPARATION OF THE INDIVIDUAL DIASTEREOMERS OF ADENYLYL-(2'-5')-P-THIOADENYLYL-(2'-5')-ADENOSINE AND THEIR 5'-PHOSPHORYLATED DERIVATIVES [J].

DEVROOM, E ;

FIDDER, A ;

SARIS, CP ;

VANDERMAREL, GA ;

VANBOOM, JH .

NUCLEIC ACIDS RESEARCH, 1987, 15 (23) :9933-9943

[10]

EPPSTEIN DA, 1982, J BIOL CHEM, V257, P13390

← 1 2 3 4 →