TOPOLOGICAL PROPERTIES OF 2 CUBIC PHASES OF A PHOSPHOLIPID-CHOLESTEROL-DIACYLGLYCEROL AQUEOUS SYSTEM AND THEIR POSSIBLE IMPLICATIONS IN THE PHOSPHOLIPASE C-INDUCED LIPOSOME FUSION

被引：77

作者：

NIEVA, JL ^{[1
]}

ALONSO, A ^{[1
]}

BASANEZ, G ^{[1
]}

GONI, FM ^{[1
]}

GULIK, A ^{[1
]}

VARGAS, R ^{[1
]}

LUZZATI, V ^{[1
]}

机构：

[1] CNRS, CTR GENET MOLEC, F-91198 GIF SUR YVETTE, FRANCE

来源：

FEBS LETTERS | 1995年 / 368卷 / 01期

关键词：

CUBIC PHASE; NON-LAMELLAR PHASE; PHOSPHOLIPID; DIACYLGLYCEROL; MEMBRANE FUSION;

D O I：

10.1016/0014-5793(95)00631-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water dispersions of phospholipid: cholesterol:diacylglycerol may, under certain conditions, originate either the lipid- and mater-permeable Q(224) cubic phase, or the lipid-permeable but water-impermeable Q(227) cubic phase, These results are discussed within the framework of the phospholipase C-induced fusion of liposomes [Nieva et al, (1993) Biochemistry 32, 1054]. It is suggested that the cubic phases Q(224) and Q(227) represnt two classes of lipid organization, one promoting, the other hindering the mixing of aqueous contents that is characteristic of membrane fusion,In this context, inverted micelles appear to be the end point of the fusion process, rather than fusion intermediates.

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页码：143 / 147

页数：5

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