THE PATHWAY OF ALLOSTERIC CONTROL AS REVEALED BY HEMOGLOBIN INTERMEDIATE STATES

被引:36
作者
HOLT, JM [1 ]
ACKERS, GK [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOPHYS,ST LOUIS,MO 63110
关键词
COOPERATIVITY; MUTANT HYBRID HEMOGLOBINS; OXYGEN BINDING; DIMER TETRAMER ASSEMBLY; THERMODYNAMIC LINKAGE;
D O I
10.1096/fasebj.9.2.7781923
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The energetics of hemoglobin cooperativity has been analyzed through the use of stable, partially-ligated intermediates. These studies revealed that the two dimeric halves of the tetramer are autonomous, leading to a Symmetry Rule that governs the relationship between ligand-binding and the T --> R quaternary switch: the R structure is favored over T only when ligands are bound to both dimers within the tetramer. A major feature of the Symmetry Rule mechanism is the generation of cooperative free energy by tertiary conformational constraints, which are formed within one dimeric half of the T-tetramer and released during the quaternary structure change to R. These rules of tertiary and quaternary molecular switching also govern the roles of the heterotropic allosteric effecters (e.g. Bohr protons).
引用
收藏
页码:210 / 218
页数:9
相关论文
共 47 条
[41]   EXPERIMENTAL RESOLUTION OF COOPERATIVE FREE-ENERGIES FOR THE 10 LIGATION STATES OF HUMAN-HEMOGLOBIN [J].
SMITH, FR ;
ACKERS, GK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (16) :5347-5351
[42]   3-STATE COMBINATORIAL SWITCHING IN HEMOGLOBIN TETRAMERS - COMPARISON BETWEEN FUNCTIONAL ENERGETICS AND MOLECULAR-STRUCTURES [J].
SMITH, FR ;
GINGRICH, D ;
HOFFMAN, BM ;
ACKERS, GK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7089-7093
[43]   EXPERIMENTAL RESOLUTION OF COOPERATIVE FREE-ENERGIES FOR THE 10 LIGATION SPECIES OF COBALT(II) IRON(II)-CO HEMOGLOBIN [J].
SPEROS, PC ;
LICATA, VJ ;
YONETANI, T ;
ACKERS, GK .
BIOCHEMISTRY, 1991, 30 (29) :7254-7262
[44]   MATHEMATICAL-MODEL FOR STRUCTURE-FUNCTION RELATIONS IN HEMOGLOBIN [J].
SZABO, A ;
KARPLUS, M .
JOURNAL OF MOLECULAR BIOLOGY, 1972, 72 (01) :163-+
[45]  
Turner B W, 1981, Methods Enzymol, V76, P596
[46]   ALLOSTERIC EFFECTS OF NUCLEOTIDE COFACTORS ON ESCHERICHIA-COLI REP HELICASE DNA-BINDING [J].
WONG, I ;
LOHMAN, TM .
SCIENCE, 1992, 256 (5055) :350-355
[47]  
YONETANI T, 1974, J BIOL CHEM, V249, P682