NMDA-INDUCED RELEASE OF NITRIC-OXIDE POTENTIATES ASPARTATE OVERFLOW FROM CEREBELLAR SLICES

被引：56

作者：

DICKIE, BGM ^{[1
]}

LEWIS, MJ ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV WALES COLL MED, DEPT PHARMACOL & THERAPEUT, HEATH PK, CARDIFF CF4 4XN, S GLAM, WALES

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

NITRIC OXIDE; N-METHYL-D-ASPARTATE; CEREBELLUM; ASPARTATE;

D O I：

10.1016/0304-3940(92)90492-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report that stimulation of neonatal rat cerebellar slices with (NMDA) released nitric oxide (NO) and also increased the release of aspartate. Inhibition of NMDA receptors with the specific antagonist. 3-((RS)-2-carboxypiperazin-4-yl)-propyl-l-phosphonic acid (CPP) prevented the NMDA-induced release of both NO and aspartate. Similar results were obtained with the inhibitor of NO synthase, N(G)-nitroarginine (N(G)-AG). The NO scavenger, haemoglobin prevented the release of aspartate. Under calcium-free conditions NMDA-induced aspartate release was abolished and NO release significantly reduced. These results indicate that NO has a physiological role in the release of aspartate.

引用

页码：145 / 148

页数：4

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