SYNTHESIS OF ISOSTERIC AND ISOPOLAR PHOSPHONATE SUBSTRATE-ANALOGS DESIGNED AS INHIBITORS FOR PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C FROM BACILLUS-CEREUS

被引：31

作者：

VINOD, TK

GRIFFITH, OH

KEANA, JFW

机构：

[1] UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

[2] UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

D O I：

10.1016/0040-4039(94)85358-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the isosteric phosphonate substrate analogue inhibitor 2 and the isopolar difluoromethylencphosphonate inhibitor 3 For phosphalidyinositol-specific phospholipase C (PI-PLC) from Bacillus cereus is described. The key step involved a trichloroacetonitrile mediated condensation between the inositol derivative 8 and the corresponding phosphonic acids 16 and 18 to establish the central P-O bond in these inhibitors

引用

页码：7193 / 7196

页数：4

共 20 条

[1] SYNTHESIS OF (ALPHA,ALPHA-DIFLUOROALKYL)PHOSPHONATES BY DISPLACEMENT OF PRIMARY TRIFLATES [J].