ALLELIC EXCLUSION AND CONTROL OF ENDOGENOUS IMMUNOGLOBULIN GENE REARRANGEMENT IN K-TRANSGENIC MICE

被引：174

作者：

RITCHIE, KA ^{[1
]}

BRINSTER, RL ^{[1
]}

STORB, U ^{[1
]}

机构：

[1] UNIV PENN, SCH VET MED, REPROD PHYSIOL LAB, PHILADELPHIA, PA 19104 USA

来源：

NATURE | 1984年 / 312卷 / 5994期

关键词：

D O I：

10.1038/312517a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hybridomas were produced from spleen cells of .kappa. transgenic mice to investigate expression of the transgenic .kappa. gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. The transgene is expressed normally and the production of a complete Ig molecule turns off light-chain gene rearrangement.

引用

页码：517 / 520

页数：4

共 34 条

[1] ACTIVITY OF MULTIPLE LIGHT CHAIN GENES IN MURINE MYELOMA CELLS PRODUCING A SINGLE, FUNCTIONAL LIGHT CHAIN
ALT, FW
ENEA, V
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BALTIMORE, D
[J]. CELL, 1980, 21 (01) : 1 - 12
[2] FUNCTIONAL AND NON-FUNCTIONAL JOINING IN IMMUNOGLOBULIN LIGHT CHAIN GENES OF A MOUSE MYELOMA
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[3] PLASMACYTOMAS WITH MORE THAN ONE IMMUNOGLOBULIN KAPPA-MESSENGER RNA - IMPLICATIONS FOR ALLELIC EXCLUSION
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09): : 5812 - 5816
[4] DUAL EXPRESSION OF LAMBDA-GENES IN THE MOPC-315 PLASMACYTOMA
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[J]. NATURE, 1981, 290 (5801) : 65 - 67
[5] COMPLETE IMMUNOGLOBULIN GENE IS CREATED BY SOMATIC RECOMBINATION
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[J]. CELL, 1978, 15 (01) : 1 - 14
[6] EXPRESSION OF A MICROINJECTED IMMUNOGLOBULIN GENE IN THE SPLEEN OF TRANSGENIC MICE
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OBRIEN, RL
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STORB, U
[J]. NATURE, 1983, 306 (5941) : 332 - 336
[7] RNA SPLICING GENERATES A VARIANT LIGHT CHAIN FROM AN ABERRANTLY REARRANGED K-GENE
CHOI, E
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WALL, R
[J]. NATURE, 1980, 286 (5775) : 776 - 779
[8] CHANCE, NECESSITY AND ANTIBODY GENE DYNAMICS
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[J]. NATURE, 1983, 303 (5912) : 23 - 26
[9] ABERRANT REARRANGEMENTS CONTRIBUTE SIGNIFICANTLY TO THE ALLELIC EXCLUSION OF IMMUNOGLOBULIN GENE-EXPRESSION
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[J]. NATURE, 1981, 290 (5805) : 372 - 378
[10] AN IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION GENE IS GENERATED FROM 3 SEGMENTS OF DNA - VH, D AND JH
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[J]. CELL, 1980, 19 (04) : 981 - 992

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