MAPPING ANTIBODY-BINDING SITES ON PROTEIN ANTIGENS

被引：12

作者：

PATERSON, Y

机构：

[1] Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia

来源：

NATURE | 1992年 / 356卷 / 6368期

关键词：

D O I：

10.1038/356456a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The large surfaces of protein antigens that interact with antibody-combining sites can be determined using deuterium-exchange labelling and two-dimensional H-1 nuclear magnetic resonance (NMR). This technique may also be applied to other protein-protein interactions to identify key residues that contribute to the affinity.

引用

页码：456 / 457

页数：2

共 14 条

[11] AN ANTIBODY-BINDING SITE ON CYTOCHROME-C DEFINED BY HYDROGEN-EXCHANGE AND 2-DIMENSIONAL NMR [J].