THE WISKOTT-ALDRICH SYNDROME - REFINEMENT OF THE LOCALIZATION ON XP AND IDENTIFICATION OF ANOTHER CLOSELY LINKED MARKER LOCUS, OATL1

被引：19

作者：

GREER, WL

PEACOCKE, M

SIMINOVITCH, KA

机构：

[1] UNIV TORONTO,MT SINAI HOSP,SAMUEL LUNENFELD RES INST,DEPT MED,ROOM 656A,600 UNIV AVE,TORONTO M5G 1X5,ONTARIO,CANADA

[2] VICTORIA GEN HOSP,DEPT PATHOL,HALIFAX B3H 2Y9,NS,CANADA

[3] UNIV TORONTO,MT SINAI HOSP,DEPT IMMUNOL,TORONTO M5G 1X5,ONTARIO,CANADA

[4] TUFTS UNIV,NEW ENGLAND MED CTR,DEPT DERMATOL,BOSTON,MA 02111

来源：

HUMAN GENETICS | 1992年 / 88卷 / 04期

关键词：

D O I：

10.1007/BF00215681

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Wiskott-Aldrich syndrome (WAS) has previously been mapped to the proximal short arm of the X chromosome between the DXS14 and DXS7 loci. In this study, further segregation analysis has been performed using a newly identified WAS family as well as an additional marker probe, HOATL1. The results indicate close linkage between the WAS and OATL1 loci (Z = 6.08 at theta = 0.00) and localize the TIMP, OATL1, DXS255, and WAS loci distal to DXS146 and the OATL1 and WAS loci proximal to TIMP. These linkage data narrow the boundaries within which the WAS locus maps to the chromosomal region bracketed by TIMP and DXS146 and support the loci order Xpter-DXS7-TIMP-(OATL1, WAS, DXS255)-DXS146.

引用

页码：453 / 456

页数：4