TTX-RESISTANT NMDA RECEPTOR-MEDIATED VOLTAGE OSCILLATIONS IN MAMMALIAN LUMBAR MOTONEURONS

被引:91
作者
HOCHMAN, S [1 ]
JORDAN, LM [1 ]
SCHMIDT, BJ [1 ]
机构
[1] UNIV MANITOBA,FAC MED,DEPT PHYSIOL,WINNIPEG,MB R3E 0W3,CANADA
关键词
D O I
10.1152/jn.1994.72.5.2559
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. Whole cell current-clamp recordings were obtained from tetrodotoxin (TTX)-isolated motoneurons in the in vitro neonatal rat spinal cord to examine the effects of N-methyl-D-aspartate (NMDA) receptor activation on membrane voltage. 2. NMDA induced rhythmic membrane voltage oscillations, and injection of current ramps revealed the presence of bistable membrane properties, the base and peak of which corresponded to the base and peak values of the voltage oscillations. 3. Nonlinear motoneuron membrane properties induced by NMDA receptor activation may be well suited to reinforce rhythmic patterns of motor output during certain behaviors such as locomotion.
引用
收藏
页码:2559 / 2562
页数:4
相关论文
共 15 条
  • [11] L-ASPARTIC ACID INDUCES A REGION OF NEGATIVE SLOPE CONDUCTANCE IN THE CURRENT-VOLTAGE RELATIONSHIP OF CULTURED SPINAL-CORD NEURONS
    MACDONALD, JF
    PORIETIS, AV
    WOJTOWICZ, JM
    [J]. BRAIN RESEARCH, 1982, 237 (01) : 248 - 253
  • [12] PERSISTENT NEGATIVE-RESISTANCE IN CAT LUMBAR MOTONEURONS
    SCHWINDT, P
    CRILL, WE
    [J]. BRAIN RESEARCH, 1977, 120 (01) : 173 - 178
  • [13] L-DOPA-INDUCED AIR-STEPPING IN DEVELOPING RATS
    VANHARTESVELDT, C
    SICKLES, AE
    PORTER, JD
    STEHOUWER, DJ
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1991, 58 (02): : 251 - 255
  • [14] WALLEN P, 1987, J NEUROSCI, V7, P2745
  • [15] POSTNATAL CHANGES IN MOTONEURON ELECTROTONIC COUPLING STUDIED IN THE INVITRO RAT LUMBAR SPINAL-CORD
    WALTON, KD
    NAVARRETE, R
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 433 : 283 - 305