HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR REFRACTORY METASTATIC GESTATIONAL TROPHOBLASTIC DISEASE

被引：24

作者：

GIACALONE, PL ^{[1
]}

BENOS, P ^{[1
]}

DONNADIO, D ^{[1
]}

LAFFARGUE, F ^{[1
]}

机构：

[1] HOP LAPEYRONIE,DEPT BONE MARROW TRANSPLANTAT,F-34295 MONTPELLIER 5,FRANCE

来源：

GYNECOLOGIC ONCOLOGY | 1995年 / 58卷 / 03期

关键词：

D O I：

10.1006/gyno.1995.1247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with gestational trophoblastic disease failed to respond to all standard multiple-agent chemotherapy and had progressive uterine disease. Total hysterectomy also proved ineffective. We therefore administered high-dose cyclophosphamide, etoposide, and melphalan with autologous bone marrow support. Severe marrow suppression followed but a complete remission was achieved and the patient remains free of disease 3 years after the completion of therapy, This result seems to confirm the value of using high-dose multiagent therapy to optimize the dose-effect of therapy regimens on drug-refractory gestational trophoblastic disease. (C) 1995 Academic Press, Inc.

引用

页码：383 / 385

页数：3

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