学术探索
学术期刊
新闻热点
数据分析
智能评审

CEREBRAL PHARMACODYNAMICS OF PHYSOSTIGMINE IN ALZHEIMERS-DISEASE INVESTIGATED USING SINGLE-PHOTON COMPUTERIZED-TOMOGRAPHY

被引：51
作者：
HUNTER, R
WYPER, DJ
PATTERSON, J
HANSEN, MT
GOODWIN, GM
机构：
[1] ROYAL EDINBURGH & ASSOC HOSP,MRC,BRAIN METAB UNIT,MORNINGSIDE PK,EDINBURGH EH8 9JZ,SCOTLAND
[2] SO GEN HOSP,INST NEUROL SCI,DEPT CLIN PHYS,WELLCOME NEUROSCI GRP,GLASGOW G51 4TF,SCOTLAND
来源：
BRITISH JOURNAL OF PSYCHIATRY | 1991年 / 158卷
基金：
英国惠康基金;
关键词：
D O I：
10.1192/bjp.158.3.351
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The effects of physostigmine on patterns of rCBF in patients with pre-senile Alzheimer's disease were studied using 99m Tc-labelled HMPAO SPECT. Regional CBF increased in the left cortex relative to right, with the most significant effect in left frontal and higher frontal regions. Measures of regional brain function, such as SPECT, are an important complement to psychological test batteries in understanding the effects in brain of putative antidementia drugs. SPECT brain imaging could extend our understanding of the action of psychotropic drugs in other major psychiatric illnesses.
引用
收藏
页码：351 / 357
页数：7
相关论文
共 45 条
[31]   ACETYLCHOLINE AND CHOLINE LEVELS IN POSTMORTEM HUMAN-BRAIN TISSUE - PRELIMINARY-OBSERVATIONS IN ALZHEIMERS-DISEASE [J].
RICHTER, JA ;
PERRY, EK ;
TOMLINSON, BE .
LIFE SCIENCES, 1980, 26 (20) :1683-1689
[32]   NEUROCHEMICAL CHARACTERISTICS OF EARLY AND LATE ONSET TYPES OF ALZHEIMERS-DISEASE [J].
ROSSOR, MN ;
IVERSEN, LL ;
REYNOLDS, GP ;
MOUNTJOY, CQ ;
ROTH, M .
BRITISH MEDICAL JOURNAL, 1984, 288 (6422) :961-964
[33]   A POSTMORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA [J].
ROSSOR, MN ;
GARRETT, NJ ;
JOHNSON, AL ;
MOUNTJOY, CQ ;
ROTH, M ;
IVERSEN, LL .
BRAIN, 1982, 105 (JUN) :313-330
[34]   CAMDEX - A STANDARDIZED INSTRUMENT FOR THE DIAGNOSIS OF MENTAL DISORDER IN THE ELDERLY WITH SPECIAL REFERENCE TO THE EARLY DETECTION OF DEMENTIA [J].
ROTH, M ;
TYM, E ;
MOUNTJOY, CQ ;
HUPPERT, FA ;
HENDRIE, H ;
VERMA, S ;
GODDARD, R .
BRITISH JOURNAL OF PSYCHIATRY, 1986, 149 :698-709
[35]  
SALETU B, 1989, BRIT J CLIN PHARMACO, V28, P1
[36]   Cholinergic Control of Blood Flow in the Cerebral Cortex of the Rat [J].
Scremin, Oscar U. ;
Rovere, Alfredo A. ;
Raynald, Augusto C. ;
Giardini, Adolfo .
STROKE, 1973, 4 (02) :232-239
[37]   PRE-SYNAPTIC CHOLINERGIC DYSFUNCTION IN PATIENTS WITH DEMENTIA [J].
SIMS, NR ;
BOWEN, DM ;
ALLEN, SJ ;
SMITH, CCT ;
NEARY, D ;
THOMAS, DJ ;
DAVISON, AN .
JOURNAL OF NEUROCHEMISTRY, 1983, 40 (02) :503-509
[38]   LOCALIZATION OF FUNCTIONAL-ACTIVITY IN THE CENTRAL NERVOUS-SYSTEM BY MEASUREMENT OF GLUCOSE-UTILIZATION WITH RADIOACTIVE DEOXYGLUCOSE [J].
SOKOLOFF, L .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1981, 1 (01) :7-36
[39]  
SOKOLOFF L, 1959, PHARMACOL REV, V11, P1
[40]   EFFECTS OF ORAL PHYSOSTIGMINE IN ALZHEIMERS-DISEASE [J].
STERN, Y ;
SANO, M ;
MAYEUX, R .
ANNALS OF NEUROLOGY, 1987, 22 (03) :306-310
12345