CHOLINERGIC RECEPTORS IN HUMAN BRAIN - EFFECTS OF AGING AND ALZHEIMER-DISEASE

被引：95

作者：

GIACOBINI, E

机构：

[1] Department of Pharmacology, Southern Illinois University School of Medicine, Springfield

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1990年 / 27卷 / 04期

关键词：

NICOTINIC RECEPTORS; MUSCARINIC RECEPTORS; NORMAL AGING BRAIN;

D O I：

10.1002/jnr.490270416

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A general review of cholinergic receptors in human brain is presented. The paper focuses upon changes in normal aging brain and in Alzheimer disease. Studies from five different approaches are reported: 1) molecular biology; 2) receptor binding studies; 3) studies with specific neurotoxins; 4) immunocytochemistry; and 5) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological Alzheimer brain with regard to cholinergic receptor localization, distribution, and function.

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页码：548 / 560

页数：13

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