DETERMINATION OF RENAL CLEARANCE OF NEOPTERIN BY A PHARMACOKINETIC APPROACH

被引：19

作者：

ESTELBERGER, W

WEISS, G

PETEK, W

PALETTA, B

WACHTER, H

REIBNEGGER, G

机构：

[1] UNIV INNSBRUCK, INST MED CHEM & BIOCHEM, FRITZ PREGL STR 3, A-6020 INNSBRUCK, AUSTRIA

[2] GRAZ UNIV, INST MED CHEM, A-8010 GRAZ, AUSTRIA

[3] GRAZ UNIV, INST MED BIOCHEM, A-8010 GRAZ, AUSTRIA

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

NEOPTERIN; RENAL CLEARANCE; GLOMERULAR FILTRATION; TUBULAR SECRETION; PHARMACOKINETICS; MATHEMATICAL MODELING;

D O I：

10.1016/0014-5793(93)80182-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmacokinetic modelling was used to determine the glomerular filtration rate and tubular secretion of neopterin, a marker for cellular immune activation. The method involves parameter identification employing the transient venous plasma concentration profiles of marker substances. By combined i.v. injection of neopterin and inulin which is excreted exclusively via glomerular filtration, neopterin was shown to be excreted in addition to glomerular filtration, by tubular secretion: clearance of inulin, 112 (S.D.2.2) ml/liter; clearance of neopterin, 499 (S.D. 79.7) ml/min. A pilot experiment using in addition p-amino hippuric acid suggests that neopterin and p-amino hippuric acid may employ the same carrier system for tubular secretion.

引用

页码：13 / 16

页数：4