EFFECTS OF ANDROGENS ON ISOLATED RAT UTERUS

被引：20

作者：

APARICIO, JAS ^{[1
]}

GUTIERREZ, M ^{[1
]}

HIDALGO, A ^{[1
]}

CANTABRANA, B ^{[1
]}

机构：

[1] FAC MED OVIEDO,DEPT MED,FARMACOL LAB,C-JULIAN CLAVERIA S-N,E-33006 OVIEDO,SPAIN

来源：

LIFE SCIENCES | 1993年 / 53卷 / 03期

关键词：

D O I：

10.1016/0024-3205(93)90678-V

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The 5alpha- and 5beta-dihydrotestosterone (DHT) androgens relax KCl-induced tonic contraction in rat uterus, in a dose-dependent way. The 5alpha and 5beta-DHT relaxing effect is counteracted by CaCl2 (0.1-10 mM). The 5alpha-DHT, but not the 5beta-DHT, effect was reduced by cycloheximide (10 mug/ml) and by actinomycin D (5 mug/ml). Flutamide at 10(-6) M shifted the effect of 5alpha-DHT to the right. However, other doses of flutamide or cyproterone acetate did not modify the effect of both androgens. We suggest a non-genomic effect of 5alpha-DHT and 5beta-DHT in rat uterus contraction but that intracellular and genomic actions play a part in the relaxing effect of 5alpha-DHT.

引用

页码：269 / 274

页数：6

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