EFFECTS OF ANTIANDROGENS AND PROGESTERONE ON ISOLATED RAT UTERUS

被引：6

作者：

APARICIO, JAS ^{[1
]}

CANTABRANA, B ^{[1
]}

HIDALGO, A ^{[1
]}

机构：

[1] FAC MED OVIEDO,DEPT MED,FARMACOL LAB,C-JULIAN CLAVERIA S-N,E-33006 OVIEDO,SPAIN

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 04期

关键词：

D O I：

10.1016/0306-3623(92)90142-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effect of progesterone (P, 6 x 10(-6)-6 x 10(-5)M) and the antiandrogens cyproterone acetate (CPA, 10(-7)-10(-5)M), flutamide (F, 10(-6)-6 x 10(-5)M) and spironolactone (S, 10(-6)-6 x 10(-5)M) on the KCl-induced tonic contraction of the isolated rat uterus have been assayed. 2. The antiandrogens relaxed, in a dose-dependent way, the KCl-induced contraction (EC50, 2.804 +/- 0.506 x 10(-6); 1.671 +/- 0.308 x 10(-5); and 3.042 +/- 0.14 x 10(-5)M, respectively for CPA, S and F). P also relaxed the KCl-induced contraction (EC50, 2.436 +/- 0.524 x 10(-5)M). 3. CaCl2 (0.1-10 mM) counteracted the relaxing effect of CPA, S, F. and P, respectively, up to 100, 80.63. 60.66 and 90.57%. 4. The 17-OH-progesterone derivative CPA. but not S or F, reduces at small doses (6 x 10(-8)M), but not at higher concentrations (6 x 10(-7)-6 x 10(-6)M), the relaxing effect of progesterone.

引用

页码：643 / 647

页数：5

共 16 条

[1] EFFECT OF ESTROGEN-TREATMENT ON CALCIUM-UPTAKE BY THE RAT UTERINE SMOOTH-MUSCLE
BATRA, S
SJOGREN, C
[J]. LIFE SCIENCES, 1983, 32 (04) : 315 - 319
[2] EFFECTS OF DIETHYLSTILBESTROL AND OVARIAN STEROIDS ON CONTRACTILE RESPONSES AND CALCIUM MOVEMENTS IN RAT UTERINE SMOOTH-MUSCLE
BATRA, S
BENGTSSON, B
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1978, 276 (MAR): : 329 - 342
[3] BATRA S, 1980, TRENDS PHARMACOL SCI, V2, P388
[4] FERNANDEZ AI, 1991, GEN PHARMACOL, V23, P549
[5] HAUKKAMAA M, 1987, STEROID HORMONE RECE, P155
[6] NON-GENOMIC AND GENOMIC EFFECTS OF STEROIDS ON NEURAL ACTIVITY
MCEWEN, BS
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (04) : 141 - 147
[7] INTERACTIONS OF SPIRONOLACTONE WITH (+)-[H-3]-ISRADIPINE AND (-)-[H-3]-DESMETHOXYVERAPAMIL BINDING-SITES IN VASCULAR SMOOTH-MUSCLE
MIRONNEAU, J
SAYET, I
RAKOTOARISOA, L
DACQUET, C
MIRONNEAU, C
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (01) : 6 - 7
[8] MOSS RL, 1984, PROGR BRAIN RES, V611, P3
[9] EFFECTS INVITRO OF PROGESTERONE AND ESTRADIOL-17-BETA ON THE CONTRACTILE AND ELECTRICAL RESPONSES IN RAT MYOMETRIUM
OSA, T
OGASAWARA, T
[J]. JAPANESE JOURNAL OF PHYSIOLOGY, 1984, 34 (03) : 427 - 441
[10] EFFECT OF PROGESTERONE ON NOREPINEPHRINE RELEASE FROM MOUSE ADRENERGIC TERMINALS INVITRO
PADILLA, L
ASENCIO, H
FERNANDEZ, W
CRUZ, MA
NEUMANN, V
REINICKE, K
RUDOLPH, MI
[J]. GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1991, 22 (04): : 647 - 650

← 1 2 →