GONADOTROPIN-RELEASING-HORMONE NEURONS IN THE RHESUS MACAQUE ARE NOT IMMUNOREACTIVE FOR THE ESTROGEN-RECEPTOR

被引：60

作者：

SULLIVAN, KA

WITKIN, JW

FERIN, M

SILVERMAN, AJ

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT ANAT & CELL BIOL,NEW YORK,NY 10032

[2] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI

[3] COLUMBIA UNIV COLL PHYS & SURG,DEPT OBSTET & GYNECOL,NEW YORK,NY 10032

来源：

BRAIN RESEARCH | 1995年 / 685卷 / 1-2期

关键词：

ESTROGEN RECEPTOR; GONADOTROPIN-RELEASING HORMONE; PREOPTIC AREA; HYPOTHALAMUS; RHESUS MACAQUE;

D O I：

10.1016/0006-8993(95)00352-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.

引用

收藏

页码：198 / 200

页数：3

相关论文

共 27 条

[1] STEROID-RECEPTOR FAMILY - STRUCTURE AND FUNCTIONS [J].

CARSONJURICA, MA ;

SCHRADER, WT ;

OMALLEY, BW .

ENDOCRINE REVIEWS, 1990, 11 (02) :201-220

[2]

ERIKSEN EF, 1988, SCIENCE, V304, P84

[3]

GERLACH JL, 1976, BRAIN RES, V103, P605

[4] LOCATION OF THE NEUROENDOCRINE GONADOTROPIN-RELEASING HORMONE NEURONS IN THE MONKEY HYPOTHALAMUS BY RETROGRADE TRACING AND IMMUNOSTAINING [J].

GOLDSMITH, PC ;

THIND, KK ;

SONG, TB ;

KIM, EJ ;

BOGGAN, JE .

JOURNAL OF NEUROENDOCRINOLOGY, 1990, 2 (02) :157-168

[5] LOCALIZATION OF ESTROGEN-RECEPTORS IN PREOPTIC NEURONS CONTAINING NEUROTENSIN BUT NOT TYROSINE-HYDROXYLASE, CHOLECYSTOKININ OR LUTEINIZING-HORMONE-RELEASING HORMONE IN THE MALE AND FEMALE RAT [J].

HERBISON, AE ;

THEODOSIS, DT .

NEUROSCIENCE, 1992, 50 (02) :283-298

[6] ATLAS OF ESTROGEN-CONCENTRATING CELLS IN CENTRAL NERVOUS-SYSTEM OF SQUIRREL-MONKEY [J].

KEEFER, DA ;

STUMPF, WE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1975, 160 (04) :419-441

[7] DO GONADOTROPIN-RELEASING-HORMONE, TYROSINE HYDROXYLASE-IMMUNOREACTIVE, AND BETA-ENDORPHIN-IMMUNOREACTIVE NEURONS CONTAIN ESTROGEN-RECEPTORS - A DOUBLE-LABEL IMMUNOCYTOCHEMICAL STUDY IN THE SUFFOLK EWE [J].

LEHMAN, MN ;

KARSCH, FJ .

ENDOCRINOLOGY, 1993, 133 (02) :887-895

[8] INVIVO GONADOTROPIN-RELEASING HORMONE-RELEASE AND SERUM LUTEINIZING-HORMONE MEASUREMENTS IN OVARIECTOMIZED, ESTROGEN-TREATED RHESUS MACAQUES [J].

LEVINE, JE ;

NORMAN, RL ;

GLIESSMAN, PM ;

OYAMA, TT ;

BANGSBERG, DR ;

SPIES, HG .

ENDOCRINOLOGY, 1985, 117 (02) :711-721

[9] NEUROREGULATORY AND NEUROENDOCRINE GNRH PATHWAYS IN THE HYPOTHALAMUS AND FOREBRAIN OF THE BABOON [J].

MARSHALL, PE ;

GOLDSMITH, PC .

BRAIN RESEARCH, 1980, 193 (02) :353-372

[10]

MOORE LM, 1994, SOC NEUROSCI, V20, P93