GONADOTROPIN-RELEASING-HORMONE NEURONS IN THE RHESUS MACAQUE ARE NOT IMMUNOREACTIVE FOR THE ESTROGEN-RECEPTOR

被引:60
作者
SULLIVAN, KA
WITKIN, JW
FERIN, M
SILVERMAN, AJ
机构
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT ANAT & CELL BIOL,NEW YORK,NY 10032
[2] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI
[3] COLUMBIA UNIV COLL PHYS & SURG,DEPT OBSTET & GYNECOL,NEW YORK,NY 10032
关键词
ESTROGEN RECEPTOR; GONADOTROPIN-RELEASING HORMONE; PREOPTIC AREA; HYPOTHALAMUS; RHESUS MACAQUE;
D O I
10.1016/0006-8993(95)00352-Q
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.
引用
收藏
页码:198 / 200
页数:3
相关论文
共 27 条
[11]   GONADOTROPIN-RELEASING HORMONE GENE-EXPRESSION DURING THE RAT ESTROUS-CYCLE - EFFECTS OF PENTOBARBITAL AND OVARIAN-STEROIDS [J].
PARK, OK ;
GUGNEJA, S ;
MAYO, KE .
ENDOCRINOLOGY, 1990, 127 (01) :365-372
[12]   STEROID-HORMONES MODULATE THE RELEASE OF IMMUNOREACTIVE GONADOTROPIN-RELEASING HORMONE FROM CULTURED HUMAN PLACENTAL CELLS [J].
PETRAGLIA, F ;
VAUGHAN, J ;
VALE, W .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) :1173-1178
[14]   AUTORADIOGRAPHIC LOCALIZATION OF HORMONE-CONCENTRATING CELLS IN BRAIN OF FEMALE RHESUS-MONKEY [J].
PFAFF, DW ;
GERLACH, JL ;
MCEWEN, BS ;
FERIN, M ;
CARMEL, P ;
ZIMMERMAN, EA .
JOURNAL OF COMPARATIVE NEUROLOGY, 1976, 170 (03) :279-+
[15]   EVIDENCE FOR DIRECT ESTROGEN REGULATION OF THE HUMAN GONADOTROPIN-RELEASING-HORMONE GENE [J].
RADOVICK, S ;
TICKNOR, CM ;
NAKAYAMA, Y ;
NOTIDES, AC ;
RAHMAN, A ;
WEINTRAUB, BD ;
CUTLER, GB ;
WONDISFORD, FE .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) :1649-1655
[16]   ESTRADIOL STIMULATES PREOPTIC AREA-ANTERIOR HYPOTHALAMIC PROGNRH-GAP GENE-EXPRESSION IN OVARIECTOMIZED RATS [J].
ROBERTS, JL ;
DUTLOW, CM ;
JAKUBOWSKI, M ;
BLUM, M ;
MILLAR, RP .
MOLECULAR BRAIN RESEARCH, 1989, 6 (2-3) :127-134
[17]   ULTRASTRUCTURAL-CHANGES IN GONADOTROPIN-RELEASING-HORMONE NEURONS AS A FUNCTION OF AGE AND OVARIECTOMY IN RATS [J].
ROMERO, MT ;
SILVERMAN, AJ ;
WISE, PM ;
WITKIN, JW .
NEUROSCIENCE, 1994, 58 (01) :217-225
[18]   INSITU HYBRIDIZATION FOR LHRH MESSENGER-RNA FOLLOWING ESTROGEN-TREATMENT [J].
ROTHFELD, J ;
HEJTMANCIK, JF ;
CONN, PM ;
PFAFF, DW .
MOLECULAR BRAIN RESEARCH, 1989, 6 (2-3) :121-125
[19]   LHRH MESSENGER-RNA IN NEURONS IN THE INTACT AND CASTRATE MALE-RAT FOREBRAIN, STUDIED BY INSITU HYBRIDIZATION [J].
ROTHFELD, JM ;
HEJTMANCIK, JF ;
CONN, PM ;
PFAFF, DW .
EXPERIMENTAL BRAIN RESEARCH, 1987, 67 (01) :113-118
[20]   ABSENCE OF ESTRADIOL CONCENTRATION IN CELL-NUCLEI OF LHRH-IMMUNOREACTIVE NEURONS [J].
SHIVERS, BD ;
HARLAN, RE ;
MORRELL, JI ;
PFAFF, DW .
NATURE, 1983, 304 (5924) :345-347