Enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (Suncus murinus) by the neurokinin(1) (NK1) receptor antagonist CP-99,994

被引：26

作者：

Tattersall, FD

Rycroft, W

Marmont, N

Cascieri, M

Hill, RG

Hargreaves, RJ

机构：

[1] Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 12期

关键词：

anti-emetic; CP-99,994; Suncus murinus; shrews; neurokinin(1) receptor; emesis;

D O I：

10.1016/0028-3908(95)00164-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of the NK1 receptor antagonist CP-99,994 on nicotine-induced emesis were examined in Suncus murinus. CP-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). CP-100,263 (3 and 10 mg/kg i.p.), the enantiomer of CP-99,994 with 1000 fold lower affinity for the NK1 receptor was without effect and RP67580 reduced emesis only at a dose of 30 mg/kg i.p. Responses to NK1 antagonists were ranked according to their affinities for the Suncus murinus NK1 receptor.

引用

页码：1697 / 1699

页数：3

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