IMAGING ENDOGENOUS DOPAMINE COMPETITION WITH [C-11] RACLOPRIDE IN THE HUMAN BRAIN

被引：333

作者：

VOLKOW, ND

WANG, GJ

FOWLER, JS

LOGAN, J

SCHLYER, D

HITZEMANN, R

LIEBERMAN, J

ANGRIST, B

PAPPAS, N

MACGREGOR, R

BURR, G

COOPER, T

WOLF, AP

机构：

[1] SUNY STONY BROOK, DEPT PSYCHIAT, STONY BROOK, NY 11794 USA

[2] VET ADM MED CTR, NORTHPORT, NY 11768 USA

[3] NYU, DEPT PSYCHIAT, NEW YORK, NY 10016 USA

[4] HILLSIDE HOSP, GLEN OAKS, NY 11004 USA

来源：

SYNAPSE | 1994年 / 16卷 / 04期

关键词：

METHYLPHENIDATE; C-11]-RACLOPRIDE; POSITRON EMISSION TOMOGRAPHY; SYNAPSE; RECEPTORS;

D O I：

10.1002/syn.890160402

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [C-11]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [C-11]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate-induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior. (C) 1994 Wiley-Liss, Inc.

引用

页码：255 / 262

页数：8