CHANGES IN SEROTONIN-IMMUNOREACTIVITY IN THE DORSAL AND MEDIAN RAPHE NUCLEI OF RATS EXPOSED TO 2,4-DICHLOROPHENOXYACETIC ACID THROUGH LACTATION

被引：23

作者：

DEDUFFARD, AME

BRUSCO, A

DUFFARD, R

GARCIA, G

SAAVEDRA, JP

机构：

[1] UNIV BUENOS AIRES,INST CELL BIOL & NEUROSCI PROF EDUARDO DE ROBERTI,BUENOS AIRES,DF,ARGENTINA

[2] UNIV BUENOS AIRES,SCH MED,MIE,LANAIS,NATL LAB RES & SERV ELECTRON MICROSCOPY,BUENOS AIRES,DF,ARGENTINA

[3] UNIV NACL ROSARIO,SCH BIOCHEM & PHARMACEUT SCI,EXPTL TOXICOL LAB,RA-2000 ROSARIO,ARGENTINA

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1995年 / 26卷 / 02期

关键词：

D O I：

10.1007/BF02815012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Comparison of serotonin-immunoreactive (SER-IR) neurons in nucleus raphe dorsalis (NRD) and median raphe nucleus (MRN) of 25-d-old rat pups exposed to 70 mg/kg/d 2,4-dichloro-phenoxyacetic acid through mothers milk and control pups was made using an immunohistochemical analysis. Significant 2,4-D-treatment-related increase in size and density of SER-IR neuronal somata as well as in fiber length were observed. We postulate that exposure to 2,4-dichlorophenoxyacetic acid on the first day of life would modify the synthesis of 5-HT or the maturation of the brain serotonergic system.

引用

页码：187 / 193

页数：7

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