BENZODIAZEPINE RECEPTORS ARE NOT INVOLVED IN THE NEUROTOXICITY AND ANTI-ELECTROSHOCK ACTIVITY OF PHENYTOIN IN MICE

被引：3

作者：

CHWEH, AY ^{[1
]}

SWINYARD, EA ^{[1
]}

WOLF, HH ^{[1
]}

机构：

[1] UNIV UTAH, COLL PHARM, DEPT BIOCHEM PHARMACOL & TOXICOL, SALT LAKE CITY, UT 84112 USA

来源：

NEUROSCIENCE LETTERS | 1985年 / 57卷 / 03期

关键词：

D O I：

10.1016/0304-3940(85)90505-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It was investigated whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin. Ro 15-1788 ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a][1,4]-benzodiazepine-3-carboxylate, a benzodiazepine receptor antagonist, reversed the anticonvulsant activity of clonazepam against both supramaximal and maximal threshold seizures induced by electroshock but not that of phenytoin. Moreover, Ro 15-1788 did not decrease the neurotoxicity of phenytoin. Benzodiazepine receptors are not involved in either the anticonvulsant action of phenytoin against seizures induced by electroshock or the neurotoxicity of phenytoin.

引用

页码：279 / 282

页数：4

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