DIRECT RELAXANT EFFECTS OF GARLIC JUICE ON SMOOTH AND CARDIAC MUSCLES

被引：46

作者：

AQEL, MB

GHARAIBAH, MN

SALHAB, AS

机构：

[1] College of Medicine, University of Jordan, Amman

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 33卷 / 1-2期

关键词：

GARLIC JUICE; AORTA; TRACHEA; INTESTINE; ISOLATED RABBIT HEART;

D O I：

10.1016/0378-8741(91)90154-6

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of garlic juice on smooth and cardiac muscles of rabbit and guinea pig were tested in vitro using isolated segments of aorta, trachea and intestines and isolated rabbit hearts. Garlic juice inhibited the contractions of rabbit and guinea pig aortic rings induced by norepinephrine in Ca2+-free and Ca2+-containing Krebs-Henseleit solutions. Also, garlic juice inhibited the contractions of rabbit and guinea pig tracheal smooth muscles induced by acetylcholine and histamine. respectively, in both Ca2+-free and Ca2+-containing Krebs-Henseleit solutions. Furthermore, garlic juice inhibited the spontaneous movements of rabbit jejunum and guinea pig ileum and inhibited the force of contraction of isolated rabbit hearts in a concentration-dependent manner. All inhibitions were reversible. These data suggest that the hypotensive action of garlic juice may be due, at least in part, to a direct relaxant effect on smooth muscles.

引用

页码：13 / 19

页数：7

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