EVIDENCE FOR A GENETIC ASSOCIATION BETWEEN ALLELES OF MONOAMINE-OXIDASE A GENE AND BIPOLAR AFFECTIVE-DISORDER

被引：74

作者：

LIM, LCC

POWELL, J

SHAM, P

CASTLE, D

HUNT, N

MURRAY, R

GILL, M

机构：

[1] INST PSYCHIAT,DEPT PSYCHOL MED,LONDON SE5 8AF,ENGLAND

[2] INST PSYCHIAT,DEPT NEUROSCI,LONDON SE5 8AF,ENGLAND

[3] CHILTERN COMMUNITY MENTAL HLTH TEAM,CHILTERN,BUCKS,ENGLAND

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1995年 / 60卷 / 04期

基金：

英国惠康基金;

关键词：

ASSOCIATION STUDY; MAOA GENE; MAOB GENE; CHROMOSOME X; AFFECTIVE DISORDER; MANIC DEPRESSION;

D O I：

10.1002/ajmg.1320600413

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism, The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB, Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions, Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes, The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant. (C) 1995 Wiley-Liss, Inc.

引用

页码：325 / 331

页数：7

共 58 条

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