LIN-31, A CAENORHABDITIS-ELEGANS HNF-3 FORK-HEAD TRANSCRIPTION FACTOR HOMOLOG, SPECIFIES 3 ALTERNATIVE CELL FATES IN VULVAR DEVELOPMENT

被引:150
作者
MILLER, LM [1 ]
GALLEGOS, ME [1 ]
MORISSEAU, BA [1 ]
KIM, SK [1 ]
机构
[1] STANFORD UNIV,MED CTR,DEPT DEV BIOL,STANFORD,CA 94305
关键词
CAENORHABDITIS-ELEGANS; LIN-31; HNF-3; FORK-HEAD; VULVAR DEVELOPMENT;
D O I
10.1101/gad.7.6.933
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cell-cell signaling controls the specification of vulval cell fates in Caenorhabditis elegans. Although previous studies have identified genes that function at early steps in the signaling pathway, the late steps are not well understood. Here, we begin to characterize those late events by showing that the lin-31 gene acts near the end of the vulval signaling pathway. We show that lin-31 acts downstream of the ras homolog let-60 and that lin-31 encodes a member of the HNF-3/fork head family of DNA-binding transcription factors. lin-31 regulates how vulval precursor cells choose their fate; in lin-31 mutants, these cells do not properly choose which fate to express and therefore adopt any one of the three possible vulval cell fates in a deregulated fashion. This interesting mutant phenotype suggests mechanisms for how vulval cell fates become determined.
引用
收藏
页码:933 / 947
页数:15
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