CLINICAL IMPORTANCE OF PERSISTENCE OF ANTICARDIOLIPIN ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：76

作者：

ISHII, Y ^{[1
]}

NAGASAWA, K ^{[1
]}

MAYUMI, T ^{[1
]}

NIHO, Y ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1,3-1-1 MAIDASHI,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1990年 / 49卷 / 06期

关键词：

D O I：

10.1136/ard.49.6.387

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44-5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody litre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p < 0-05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p < 0-05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.

引用

页码：387 / 390

页数：4

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