ACTIVATION OF CYCLIN E-DEPENDENT KINASE BY DNA-DAMAGE SIGNALS DURING APOPTOSIS

被引：31

作者：

DOU, QP ^{[1
]}

AN, B ^{[1
]}

YU, C ^{[1
]}

机构：

[1] UNIV PITTSBURGH,INST CANC,DIV BASIC RES,PITTSBURGH,PA 15213

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preexposure of HL-60 cells to a DNA-damaging agent, cytosine arabinoside (Ara-C), dramatically induced the levels of H1 kinase activities associated with cyclin E (CycE-H1K) but not cyclin A. This induction was cell cycle-independent and accompanied by loss of cell viability, a late event in apoptosis. When an Ara-C-resistant variant of HL-60 cells was treated with Ara-C at a low concentration, neither CycE-H1K nor apoptosis were observed. Both events were induced in the resistant cells but only after treatment with Ara-C at a much higher concentration for a longer period. The DNA-damage-induced CycE-H1K is proposed to be involved in a late apoptosis checkpoint. (C) 1995 Academic Press, Inc.

引用

页码：771 / 780

页数：10