ANOREXIA FOLLOWING THE SYSTEMIC INJECTION OF AMYLIN

被引：64

作者：

CHANCE, WT ^{[1
]}

BALASUBRAMANIAM, A ^{[1
]}

STALLION, A ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH

来源：

BRAIN RESEARCH | 1993年 / 607卷 / 1-2期

关键词：

ANOREXIA; DIABETES-ASSOCIATED PEPTIDE; CORPUS STRIATUM; HYPOTHALAMUS; 3-METHOXYTYRAMINE; DOPAMINE; SEROTONIN; GLUCOSE; CALCITONIN GENE-RELATED PEPTIDE;

D O I：

10.1016/0006-8993(93)91505-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intravenous injection of 100 mug/kg of rat amylin reduced food intake in schedule-fed rats for 1 h of an 8 h measurement period. Associated with this brief anorexia was a hyperglycemic response, observed 30 min after a subsequent amylin administration. Determination of neurochemical alterations revealed increased concentration of serotonin in the hypothalamus and decreased level of the dopamine metabolite, 3-methoxytyramine, in the corpus striatum. Since similar neurochemical alterations were observed following the systemic injection of glucose, both the neurochemical changes and anorexia following intravenous amylin treatment may be secondary to hyperglycemia.

引用

页码：185 / 188

页数：4

共 29 条

[1] REGIONAL DISTRIBUTION AND MOLECULAR-FORMS OF RAT ISLET AMYLOID POLYPEPTIDE
ASAI, J
NAKAZATO, M
MIYAZATO, M
KANGAWA, K
MATSUO, H
MATSUKURA, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (02) : 788 - 795
[2] ISOLATION AND SEQUENCE DETERMINATION OF RAT ISLET AMYLOID POLYPEPTIDE
ASAI, J
NAKAZATO, M
KANGAWA, K
MATSUKURA, S
MATSUO, H
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) : 400 - 405
[3] SYNTHESES, STRUCTURES AND ANORECTIC EFFECTS OF HUMAN AND RAT AMYLIN
BALASUBRAMANIAM, A
RENUGOPALAKRISHNAN, V
STEIN, M
FISCHER, JE
CHANCE, WT
[J]. PEPTIDES, 1991, 12 (05) : 919 - 924
[4] BLUNDELL JE, 1979, SEROTONIN HLTH DISEA, P403
[5] INTERSTITIAL 3-METHOXYTYRAMINE REFLECTS STRIATAL DOPAMINE RELEASE - AN INVIVO MICRODIALYSIS STUDY
BROWN, EE
DAMSMA, G
CUMMING, P
FIBIGER, HC
[J]. JOURNAL OF NEUROCHEMISTRY, 1991, 57 (02) : 701 - 707
[6] ONLINE CONTINUOUS MEASUREMENT OF BLOOD-GLUCOSE AND MEAL PATTERN IN FREE-FEEDING RATS - THE ROLE OF GLUCOSE IN MEAL INITIATION
CAMPFIELD, LA
BRANDON, P
SMITH, FJ
[J]. BRAIN RESEARCH BULLETIN, 1985, 14 (06) : 605 - 616
[7] NEUROTRANSMITTER ALTERATIONS ASSOCIATED WITH FEEDING AND SATIETY
CHANCE, WT
FOLEYNELSON, T
NELSON, JL
FISCHER, JE
[J]. BRAIN RESEARCH, 1987, 416 (02) : 228 - 234
[8] BRAIN 3-METHOXYTYRAMINE VARIES INVERSELY WITH BLOOD-GLUCOSE IN DECAPITATED RATS
CHANCE, WT
CAO, LQ
FISCHER, JE
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (02) : 553 - 556
[9] ANOREXIA FOLLOWING THE INTRAHYPOTHALAMIC ADMINISTRATION OF AMYLIN
CHANCE, WT
BALASUBRAMANIAM, A
ZHANG, FS
WIMALAWANSA, SJ
FISCHER, JE
[J]. BRAIN RESEARCH, 1991, 539 (02) : 352 - 354
[10] CHANCE WT, IN PRESS PEPTIDES

← 1 2 3 →