NONSTEROIDAL ANTIINFLAMMATORY AGENTS .17. INHIBITION OF BOVINE CYCLOOXYGENASE AND 5-LIPOXYGENASE BY N-ALKYLDIPHENYL-PYRROLYL ACETIC AND PROPIONIC-ACID DERIVATIVES

被引：14

作者：

DANNHARDT, G

LEHR, M

机构：

[1] Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität, Frankfurt, 6000

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 03期

关键词：

D O I：

10.1002/ardp.19933260308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 19 N-alkyl-diarylpyrrolyl-acetic and -propionic acid derivatives was synthesized and tested. Using bovine blood as enzyme source the inhibition of cyclooxygenase and 5-lipoxygenase, respectively, was applied to determine the antiinflammatory activity. In general all compounds tested inhibit 5-lipoxygenase more effectively than cyclooxygenase. A structure-activity relationship is discussed.

引用

页码：157 / 162

页数：6

共 10 条

[1]

ADACHI I, 1969, TETRAHEDRON LETT, V55, P4875

[2] INVITRO EVALUATION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS USING BOVINE NEUTROPHILS AND PLATELETS AND HPLC [J].