OVARIAN-FUNCTION SUPPRESSION WITH THE GONADOTROPIN-RELEASING-HORMONE (GNRH) ANALOG GOSERELIN IN PREMENOPAUSAL ADVANCED BREAST-CANCER

被引：14

作者：

BAJETTA, E ^{[1
]}

CELIO, L ^{[1
]}

ZILEMBO, N ^{[1
]}

BONO, A ^{[1
]}

GALLUZZO, D ^{[1
]}

ZAMPINO, MG ^{[1
]}

LONGHI, A ^{[1
]}

FERRARI, L ^{[1
]}

BUZZONI, R ^{[1
]}

机构：

[1] IST NAZL STUDIO & CURA TUMORI,DIV SURG & DIAGNOST ONCOL,I-20133 MILAN,ITALY

来源：

TUMORI | 1994年 / 80卷 / 01期

关键词：

BREAST CANCER; MEDICAL CASTRATION; GNRH ANALOG;

D O I：

10.1177/030089169408000105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims and background: Goserelin is a gonadotrophin-releasing hormone (GnRH) analogue that induces the suppression of gonadal steroidogenesis, and it could therefore be a medical alternative to irreversible surgical castration. We report the clinical and endocrine results from 40 goserelin-treated premenopausal patients with advanced breast cancer. Methods: A depot formulation of the drug (3.6 mg s.c.) was administered fortnightly for the first 4 doses, and monthly thereafter. Gonadotrophins and estradiol (E2) levels were measured before and at specific times during the treatment. Results: Objective responses were observed in 17 of the 38 evaluable patients (45%), six of whom achieved complete remission. The best responses were observed on soft tissues (65%). Castration E2 levels were achieved in all of the patients. Conclusions: Our results confirm that goserelin is as effective as surgical oophorectomy in premenopausal advanced breast cancer.

引用

页码：28 / 32

页数：5

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