A UNIQUELY MODIFIED RNA - INTRODUCTION OF A SINGLE RNA CLEAVAGE AGENT INTO THE M1 RIBOZYME

被引：5

作者：

RICHARDSON, PL

GROSS, ML

LIGHTWAHL, KJ

SMITH, RD

SCHEPARTZ, A

机构：

[1] YALE UNIV, DEPT CHEM, NEW HAVEN, CT 06511 USA

[2] PACIFIC NW LAB, DEPT CHEM SCI, RICHLAND, WA 99352 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)80116-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe an efficient, Sour-step synthesis of an N-4-modified cytidine phosphoramidite reagent (1) that permits nonnative functionality tp be introduced into a synthetic oligoribonucleotide. This reagent was used to prepare a 377-nt E. coli M1 ribozyme equipped with a single RNA cleavage agent at nucleotide 11.

引用

页码：2133 / 2138

页数：6

共 47 条

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