ASSIGNMENT OF GENES ENCODING A UNIQUE CYTOKINE (IL12) COMPOSED OF 2 UNRELATED SUBUNITS TO CHROMOSOME-3 AND CHROMOSOME-5

被引：125

作者：

SIEBURTH, D

JABS, EW

WARRINGTON, JA

LI, X

LASOTA, J

LAFORGIA, S

KELLEHER, K

HUEBNER, K

WASMUTH, JJ

WOLF, SF

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIATR & MED,CTR MED GENET,BALTIMORE,MD 21205

[2] THOMAS JEFFERSON UNIV,PHILADELPHIA,PA 19107

[3] UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717

来源：

GENOMICS | 1992年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0888-7543(05)80283-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2. © 1992 Academic Press, Inc. All rights reserved.

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页码：59 / 62

页数：4

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