APOMORPHINE INDUCTION OF AP-1 DNA-BINDING IN THE RAT STRIATUM AFTER DOPAMINE DEPLETION

被引：38

作者：

PENNYPACKER, KR

ZHANG, WQ

YE, H

HONG, JS

机构：

[1] Neuropharmacology Section, Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 15卷 / 1-2期

关键词：

TRANSCRIPTION FACTOR; STRIATUM; 6-HYDROXYDOPAMINE; JUN PROTEIN; FOS-RELATED ANTIGEN; C-FOS PROTEIN; AP-1 DNA BINDING;

D O I：

10.1016/0169-328X(92)90163-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of AP-1 transcription factors was assessed in the dopamine-depleted rat striatum over a 1 week period of repeated apomorphine injections. A single injection of apomorphine increased the expression of a 35 kDa Fos-related antigen and Jun proteins and their expression continued to increase until day 3 of repeated apomorphine treatment in dopamine-depleted striata. Apomorphine induces AP-1 transcription factors which may be involved in modulating gene expression in the striatum.

引用

页码：151 / 155

页数：5

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