STRICT PEPTIDE LENGTH IS NOT REQUIRED FOR THE INDUCTION OF CYTOTOXIC T-LYMPHOCYTE-MEDIATED ANTIVIRAL PROTECTION BY PEPTIDE VACCINATION

被引:49
作者
KAST, WM [1 ]
BRANDT, RMP [1 ]
MELIEF, CJM [1 ]
机构
[1] LEIDEN UNIV HOSP, BLOOD BANK, 2333 AA LEIDEN, NETHERLANDS
关键词
PEPTIDE VACCINATION; CYTOTOXIC T-LYMPHOCYTE; SENDAI VIRUS; ADJUVANT; ANTIVIRAL PROTECTION;
D O I
10.1002/eji.1830230534
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sendai virus nuclear protein peptides of different lengths were titrated in peptide vaccination experiments. We observed that peptide length was not important in inducing cytotoxic T lymphocyte-mediated protective immunity in vivo against a challenge with a lethal dose of virus. These results suggest that long peptides are trimmed in vivo to peptides that fit into the groove of major histocompatibility complex class I molecules. In addition several adjuvants were screened for their effectiveness in peptide vaccination protocols. Incomplete Freund's adjuvant and Titermax(TM) turned out to be useful, whereas alum was much less effective.
引用
收藏
页码:1189 / 1192
页数:4
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