CERVICAL FETAL FIBRONECTIN CORRELATES TO CERVICAL RIPENING

被引:19
作者
EKMAN, G
GRANSTROM, L
MALMSTROM, A
SENNSTROM, M
SVENSSON, J
机构
[1] KAROLINSKA HOSP, DEPT OBSTET & GYNAECOL, S-17176 STOCKHOLM, SWEDEN
[2] LUND UNIV, DEPT PHYSIOL CHEM, LUND, SWEDEN
[3] KAROLINSKA INST, DANDERYD HOSP, DEPT CLIN CHEM, STOCKHOLM, SWEDEN
关键词
CERVICAL RIPENING; FETAL FIBRONECTIN; PROSTAGLANDIN E(2);
D O I
10.3109/00016349509021177
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim of study. It is well established that the cervical ripeness is of great prognostic value at labor induction. The available methods of measuring the cervical ripeness are not satisfactory. This study was therefore initiated to investigate if there is any correlation between cervical fetal fibronectin and cervical ripening at term. Method Three groups were included in this study: women with unripe cervices, women with spontaneous cervical ripening and those with PGE(2)-induced cervical ripening. Fetal fibronectin was measured by ELIZA after sampling from the cervical canal. Results. The cervical fetal fibronectin was low in women with unripe cervices. In women with favorable cervices a ten fold higher level was found. The fibronectin level was even higher after PGE(2)-induced ripening. Conclusion. Conclusively an increased amount of cervical fetal fib ronectin is registered during the cervical ripening process. A level of >0.80 mu g/ml of cervical fetal fibronectin seems to indicate a favorable cervix.
引用
收藏
页码:698 / 701
页数:4
相关论文
共 24 条
[21]   INTERLEUKIN-1 (IL-1) REGULATION OF HUMAN ENDOMETRIAL FUNCTION - PRESENCE OF IL-1 RECEPTOR CORRELATES WITH IL-1-STIMULATED PROSTAGLANDIN-E2 PRODUCTION [J].
TABIBZADEH, S ;
KAFFKA, KL ;
SATYASWAROOP, PG ;
KILIAN, PL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) :1000-1006
[22]  
ULDBJERG N, 1983, AM J OBSTET GYNECOL, V147, P662, DOI 10.1016/0002-9378(83)90446-5
[23]  
ULMSTEN U, 1982, OBSTET GYNECOL, V59, P336
[24]   SIGNAL TRANSDUCTION THROUGH THE FIBRONECTIN RECEPTOR INDUCES COLLAGENASE AND STROMELYSIN GENE-EXPRESSION [J].
WERB, Z ;
TREMBLE, PM ;
BEHRENDTSEN, O ;
CROWLEY, E ;
DAMSKY, CH .
JOURNAL OF CELL BIOLOGY, 1989, 109 (02) :877-889