INTRAMOLECULAR HYDROGEN TRANSFER-REACTIONS OF ORTHO-(BROMOPHENYL)DIALKYLSILYL ETHERS - PREPARATION OF RAPAMYCIN-D1

被引：48

作者：

CURRAN, DP ^{[1
]}

SOMAYAJULA, KV ^{[1
]}

YU, HS ^{[1
]}

机构：

[1] UNIV PITTSBURGH,MASS SPECTROMETRY LAB,PITTSBURGH,PA 15260

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 17期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)74194-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical translocations of o-(bromophenyl)dimethylsilyl ethers are efficient, but yields of alpha-silyloxy alkyl radicals formed by 1,5-hydrogen transfer are limited to 65-90% by competing 1,6- and 1,7-hydrogen transfers. Similarities in substituent effects on 1,5-hydrogen transfers and radical cyclizations are identified.

引用

页码：2295 / 2298

页数：4

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