THE DOPAMINE D3-RECEPTOR - A POSTSYNAPTIC RECEPTOR INHIBITORY ON RAT LOCOMOTOR-ACTIVITY

被引：267

作者：

WATERS, N

SVENSSON, K

HAADSMASVENSSON, SR

SMITH, MW

CARLSSON, A

机构：

[1] UPJOHN CO,UPJOHN LABS,MED CHEM RES,KALAMAZOO,MI 49001

[2] UPJOHN CO,UPJOHN LABS,CHEM & BIOL SCREENING,KALAMAZOO,MI 49001

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1993年 / 94卷 / 01期

关键词：

DOPAMINE; RELEASE; D3-RECEPTOR; LOCOMOTOR ACTIVITY; RAT;

D O I：

10.1007/BF01244979

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report on the pharmacological effects of the 20 fold D 3 vs. D 2 dopamine receptor preferring compound U 99194 A. It is shown that U 99194 A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the striatum or the nucleus accumbens significantly. The data do not support any direct agonist action of U 99194 A at dopamine receptors. It is suggested that U 99194 A can antagonise a population of postsynaptic dopamine receptors involved in the suppression of some aspects of psychomotor activity. These postsynaptic receptors presumably belong to the D 3 receptor subtype.

引用

页码：11 / 19

页数：9

共 21 条

[1]

ANDEN NE, 1980, ADRENERGIC ACTIVAT 1, P429

[2] LOCALIZATION OF DOPAMINE-D3 RECEPTOR MESSENGER-RNA IN THE RAT-BRAIN USING INSITU HYBRIDIZATION HISTOCHEMISTRY - COMPARISON WITH DOPAMINE-D2 RECEPTOR MESSENGER-RNA [J].