RESPONSE TO ADJUVANT CHEMOTHERAPY IN PRIMARY BREAST-CANCER - NO CORRELATION WITH EXPRESSION OF GLUTATHIONE S-TRANSFERASES

被引：33

作者：

PETERS, WHM

ROELOFS, HMJ

VANPUTTEN, WLJ

JANSEN, JBMJ

KLIJN, JGM

FOEKENS, JA

机构：

[1] ST RADBOUD HOSP,DEPT GASTROENTEROL,6500 HB NIJMEGEN,NETHERLANDS

[2] DANIEL DENHOED CANC CTR,DEPT STAT,3008 AE ROTTERDAM,NETHERLANDS

[3] DANIEL DENHOED CANC CTR,DEPT MED ONCOL,DIV ENDOCRINE ONCOL,3008 AE ROTTERDAM,NETHERLANDS

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 68卷 / 01期

关键词：

D O I：

10.1038/bjc.1993.291

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Of 139 node-positive breast cancer patients treated with adjuvant chemotherapy, the pre-treatment levels of glutathione S-transferase (GST) classes alpha, mu and pi, were determined by immuno-quantification on Western blots in cytosols of the primary tumours. Their expression was studied with respect to cytosolic oestrogen-receptor, progesterone-receptor and cathepsin b levels, and to the length of disease-free survival. GST class pi was negatively correlated with oestrogen receptor and progesterone receptor, and positively correlated with cathepsin D. There was no correlation between GST isoenzymes and the length of disease-free survival. These data suggest that glutathione S-transferases are not useful as markers to predict the response to adjuvant chemotherapy in human breast cancer.

引用

页码：86 / 92

页数：7