HARAMERHEAD RIBOZYME-MEDIATED CLEAVAGE OF A SUBSTRATE-ANALOG CONTAINING AN INTERNUCLEOTIDIC BRIDGING 5'-PHOSPHOROTHIOATE - IMPLICATIONS FOR THE CLEAVAGE MECHANISM AND THE CATALYTIC ROLE OF THE METAL COFACTOR

被引:54
作者
KUIMELIS, RG [1 ]
MCLAUGHLIN, LW [1 ]
机构
[1] BOSTON COLL,MERKERT CHEM CTR,DEPT CHEM,CHESTNUT HILL,MA 02167
关键词
D O I
10.1021/ja00149a030
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:11019 / 11020
页数:2
相关论文
共 48 条
[1]   STRUCTURAL BASIS FOR THE 3'-5' EXONUCLEASE ACTIVITY OF ESCHERICHIA-COLI DNA-POLYMERASE-I - A 2 METAL-ION MECHANISM [J].
BEESE, LS ;
STEITZ, TA .
EMBO JOURNAL, 1991, 10 (01) :25-33
[2]   EVIDENCE FOR THE ROLE OF SOLVATED METAL HYDROXIDE IN THE HAMMERHEAD CLEAVAGE MECHANISM [J].
DAHM, SC ;
DERRICK, WB ;
UHLENBECK, OC .
BIOCHEMISTRY, 1993, 32 (48) :13040-13045
[3]   ROLE OF DIVALENT METAL-IONS IN THE HAMMERHEAD RNA CLEAVAGE REACTION [J].
DAHM, SC ;
UHLENBECK, OC .
BIOCHEMISTRY, 1991, 30 (39) :9464-9469
[4]   CHARACTERIZATION OF DEOXY-CONTAINING AND RIBO-CONTAINING OLIGONUCLEOTIDE SUBSTRATES IN THE HAMMERHEAD SELF-CLEAVAGE REACTION [J].
DAHM, SC ;
UHLENBECK, OC .
BIOCHIMIE, 1990, 72 (11) :819-823
[5]  
EADIE JS, 1987, ANAL BIOCHEM, V165, P422
[6]   SELF-CLEAVAGE OF VIRUSOID RNA IS PERFORMED BY THE PROPOSED 55-NUCLEOTIDE ACTIVE-SITE [J].
FORSTER, AC ;
SYMONS, RH .
CELL, 1987, 50 (01) :9-16
[7]  
FOSTER AC, 1987, CELL, V49, P211
[8]   COCRYSTAL STRUCTURE OF AN EDITING COMPLEX OF KLENOW FRAGMENT WITH DNA [J].
FREEMONT, PS ;
FRIEDMAN, JM ;
BEESE, LS ;
SANDERSON, MR ;
STEITZ, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :8924-8928
[9]   IMPORTANCE OF SPECIFIC PURINE AMINO AND HYDROXYL-GROUPS FOR EFFICIENT CLEAVAGE BY A HAMMERHEAD RIBOZYME [J].
FU, DJ ;
MCLAUGHLIN, LW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3985-3989
[10]   IMPORTANCE OF SPECIFIC GUANOSINE N7-NITROGENS AND PURINE AMINO-GROUPS FOR EFFICIENT CLEAVAGE BY A HAMMERHEAD RIBOZYME [J].
FU, DJ ;
RAJUR, SB ;
MCLAUGHLIN, LW .
BIOCHEMISTRY, 1993, 32 (40) :10629-10637