EVOLUTION OF ATP-BINDING CASSETTE TRANSPORTER GENES

被引：197

作者：

DEAN, M

ALLIKMETS, R

机构：

[1] National Cancer Institute Frederick Cancer Research, Development Center, Frederick, MD 21702-1201, Building 560

[2] R Allikmets, National Cancer Institute Frederick Cancer Research, Development Center, Frederick, MD 21702-1201, Building 560

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0959-437X(95)80011-S

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found in abundance in the genomes of both prokaryotes and eukaryotes. By using gene disruption techniques and by studying homologous genes in model organisms, significant progress has been made during the last few years in evaluating the physiological functions of ABC proteins in higher eukaryotes.

引用

页码：779 / 785

页数：7

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