Chromatin modifications and the DNA damage response to ionizing radiation

被引:50
作者
Kumar, Rakesh [1 ]
Horikoshi, Nobuo [1 ]
Singh, Mayank [1 ]
Gupta, Arun [1 ]
Misra, Had S. [1 ,2 ]
Albuquerque, Kevin [1 ]
Hunt, Clayton R. [1 ]
Pandita, Tej K. [1 ]
机构
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
[2] Bhabha Atom Res Ctr, Mol Biol Div, Mol Genet Sect, Homi Bhabha Natl Inst, Bombay, Maharashtra, India
来源
FRONTIERS IN ONCOLOGY | 2013年 / 2卷
基金
美国国家卫生研究院;
关键词
histone modifications; DNA repair;
D O I
10.3389/fonc.2012.00214
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In order to survive, cells have evolved highly effective repair mechanisms to deal with the potentially lethal DNA damage produced by exposure to endogenous as well as exogenous agents. Ionizing radiation exposure induces highly lethal DNA damage, especially DNA double-strand breaks (DSBs), that is sensed by the cellular machinery and then subsequently repaired by either of two different DSB repair mechanisms: (1) non homologous end joining, which re-ligates the broken ends of the DNA and (2) homologous recombination, that employs an undamaged identical DNA sequence as a template, to maintain the fidelity of DNA repair. Repair of DSBs must occur within the natural context of the cellular DNA which, along with specific proteins, is organized to form chromatin, the overall structure of which can impede DNA damage site access by repair proteins. The chromatin complex is a dynamic structure and is known to change as required for ongoing cellular processes such as gene transcription or DNA replication. Similarly, during the process of DNA damage sensing and repair, chromatin needs to undergo several changes in order to facilitate accessibility of the repair machinery. Cells utilize several factors to modify the chromatin in order to locally open up the structure to reveal the underlying DNA sequence but post-translational modification of the histone components is one of the primary mechanisms. In this review, we will summarize chromatin modifications by the respective chromatin modifying factors that occur during the DNA damage response.
引用
收藏
页数:9
相关论文
共 118 条
[101]   The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage [J].
Stewart, Grant S. ;
Panier, Stephanie ;
Townsend, Kelly ;
Al-Hakim, Abdallah K. ;
Kolas, Nadine K. ;
Miller, Edward S. ;
Nakada, Shinichiro ;
Ylanko, Jarkko ;
Olivarius, Signe ;
Mendez, Megan ;
Oldreive, Ceri ;
Wildenhain, Jan ;
Tagliaferro, Andrea ;
Pelletier, Laurence ;
Taubenheim, Nadine ;
Durandy, Anne ;
Byrd, Philip J. ;
Stankovic, Tatjana ;
Taylor, A. Malcolm R. ;
Durocher, Daniel .
CELL, 2009, 136 (03) :420-434
[102]   MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks [J].
Stucki, M ;
Clapperton, JA ;
Mohammad, D ;
Yaffe, MB ;
Smerdon, SJ ;
Jackson, SP .
CELL, 2005, 123 (07) :1213-1226
[103]   Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 [J].
Sun, Yingli ;
Jiang, Xiaofeng ;
Xu, Ye ;
Ayrapetov, Marina K. ;
Moreau, Lisa A. ;
Whetstine, Johnathan R. ;
Price, Brendan D. .
NATURE CELL BIOLOGY, 2009, 11 (11) :1376-U273
[104]   Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair [J].
Tamburini, BA ;
Tyler, JK .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (12) :4903-4913
[105]   MICROCOCCAL NUCLEASE - ITS SPECIFICITY AND USE FOR CHROMATIN ANALYSIS [J].
TELFORD, DJ ;
STEWART, BW .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1989, 21 (02) :127-137
[106]   HISTONE-H4 ISOFORMS ACETYLATED AT SPECIFIC LYSINE RESIDUES DEFINE INDIVIDUAL CHROMOSOMES AND CHROMATIN DOMAINS IN DROSOPHILA POLYTENE NUCLEI [J].
TURNER, BM ;
BIRLEY, AJ ;
LAVENDER, J .
CELL, 1992, 69 (02) :375-384
[107]   Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4 [J].
Utley, RT ;
Lacoste, N ;
Jobin-Robitaille, O ;
Allard, S ;
Côté, J .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (18) :8179-8190
[108]   Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks [J].
van Attikum, Haico ;
Fritsch, Olivier ;
Gasser, Susan M. .
EMBO JOURNAL, 2007, 26 (18) :4113-4125
[109]  
Van Hooser A, 1998, J CELL SCI, V111, P3497
[110]   Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger [J].
Wang, Gang G. ;
Song, Jikui ;
Wang, Zhanxin ;
Dormann, Holger L. ;
Casadio, Fabio ;
Li, Haitao ;
Luo, Jun-Li ;
Patel, Dinshaw J. ;
Allis, C. David .
NATURE, 2009, 459 (7248) :847-U6